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Abdomen The area within a few inches around your belly button (avoid the belly button) Thigh The space between one hand above your knee and one hand below your groin, towards the outer side of the thigh How to self-administer the injection Wash and dry hands with soap and water Clean the area of skin you intend to inject with an alcohol wipe Hold the syringe in your dominant hand with the barrel of the syringe between your fingers and your thumb on the plunger With your other hand pinch an area of skin between your fingers to create a lump Insert the needle all the way into the skin Press down the plunger while keeping the needle still Use the markings on the barrel to give the amount you have been instructed to Remove the needle at the same angle Dispose of the needle in the sharps box Wipe the area with a piece of gauze Hints and Tips Rotate between different body areas for injections For example

Neurology 99, e1402e1413

Fenofibrate, a PPAR- agonist, has shown potential in improving SS-like symptoms, such as dacryoadenitis in NOD mice, by modulating Th1/Th17 and Treg cell responses, partly through upregulation of the PPAR-/LXR- signaling pathway [129]

There is every reason to argue that the efficacy observed for compounds 1 and 2 in vivo incorporates a similar role for the host immune response as seen for other schistosomicidal agents

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